Alternative transcripts of fatty acid desaturase (FADS) genes
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چکیده
منابع مشابه
The fatty acid desaturase 3 gene encodes for different FADS 3 protein isoforms in mammalian tissues
This article is available online at http://www.jlr.org derived from the biosynthetic pathways resulting in the conversion of essential precursors to their respective elongated polyenoic products. The availability of PUFA in mammalian cells greatly depends on the activity of enzymes involved in FA metabolism. In animals and humans, the 5and 6-desaturases are the pivotal enzymes introducing de no...
متن کاملFADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes
Polyunsaturated fatty acids (PUFA) correlate with risk of dyslipidemia and cardiovascular diseases. Fatty acid desaturase (FADS) single nucleotide polymorphisms (SNPs) modulate circulating PUFA concentrations. This study examined influence of FADS1 and FADS2 genetic variants on desaturase activities and blood lipid concentrations in type 2 diabetes patients, and further assessed their interrela...
متن کاملFatty acid desaturase mutants of Saccharomyces cerevisiae.
Genetic and biochemical analyses were conducted on fatty acid mutants of yeast deficient for Delta(9)-desaturase activity in the production of palmitoleate and oleate. Two genetic loci were observed and two others are inferred; three of these were represented by respiratory-deficient (petite) strains. All strains were incapable of converting palmitate to palmitoleate and stearate to oleate whet...
متن کاملFatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study
BACKGROUND We investigated the relationship between fatty acid desaturase (FADS) gene polymorphisms and insulin resistance (IR) in association with serum phospholipid polyunsaturated fatty acid (FA) composition in healthy Korean men. METHODS Healthy men (n = 576, 30 ~ 79 years old) were genotyped for rs174537 near FADS1 (FEN1-10154G>T), FADS2 (rs174575C>G, rs2727270C>T), and FADS3 (rs1000778C...
متن کاملContribution of the different omega-3 fatty acid desaturase genes to the cold response in soybean
This study analysed the contribution of each omega-3 desaturase to the cold response in soybean. Exposure to cold temperatures (5 °C) did not result in great modifications of the linolenic acid content in leaf membrane lipids. However, an increase in the GmFAD3A transcripts was observed both in plant leaves and soybean cells whereas no changes in GmFAD3B or GmFAD3C expression levels were detect...
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ژورنال
عنوان ژورنال: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
سال: 2010
ISSN: 0952-3278
DOI: 10.1016/j.plefa.2010.02.011